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	<title>Traumatic Brain Injury Centers &#187; Research trends</title>
	<atom:link href="http://www.traumaticbraininjurycenters.com/category/research-trends/feed/" rel="self" type="application/rss+xml" />
	<link>http://www.traumaticbraininjurycenters.com</link>
	<description>Function, Education and Research</description>
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		<title>IQ, Poverty and Culture</title>
		<link>http://www.traumaticbraininjurycenters.com/2009/10/iq-poverty-and-culture/</link>
		<comments>http://www.traumaticbraininjurycenters.com/2009/10/iq-poverty-and-culture/#comments</comments>
		<pubDate>Thu, 01 Oct 2009 21:33:15 +0000</pubDate>
		<dc:creator>empower2go</dc:creator>
				<category><![CDATA[Brain and coping]]></category>
		<category><![CDATA[Encourage]]></category>
		<category><![CDATA[Research trends]]></category>
		<category><![CDATA[brain fog]]></category>
		<category><![CDATA[brain potential]]></category>
		<category><![CDATA[building memory strategies]]></category>
		<category><![CDATA[cognition]]></category>
		<category><![CDATA[Genes]]></category>
		<category><![CDATA[intellectual enhancement]]></category>
		<category><![CDATA[neural plasticity]]></category>
		<category><![CDATA[thinking help]]></category>

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		<description><![CDATA[Nationally, African American students are identified as educationally mentally retarded twice as often as their white peers; and African Americans are identified as emotionally/behaviorally disordered one and a half times as often as their white peers. The actual number of these "BD" (Behavioral Disorder) diagnoses has increased by 500% between 1974 and 1998.”]]></description>
			<content:encoded><![CDATA[<div id="attachment_289" class="wp-caption alignleft" style="width: 310px"><a rel="attachment wp-att-289" href="http://empower2go.wordpress.com/2009/10/01/iq-poverty-and-culture/color-hands/"><img class="size-medium wp-image-289" title="color hands" src="http://empower2go.files.wordpress.com/2009/10/color-hands.jpg?w=300" alt="Change Ethnic Poverty" width="300" height="286" /></a><p class="wp-caption-text">Change Ethnic Poverty</p></div>
<p>Students of African American and Hispanic background were recently part of a pilot project using a novel system of cognitive assessment to assess children&#8217;s learning potential. It was developed by <a href="http://www.israel21c.org/index.php?option=com_content&amp;view=article&amp;id=1696&amp;catid=61:social-action&amp;Itemid=140" target="_blank">Professor Reuven Feuerstein</a>. The assessment consists of a battery of six to eight tests which measure abstract thinking, analogies, and qualitative thinking and are not culturally-biased.</p>
<p>“Nationally, African American students are identified as educationally mentally retarded twice as often as their white peers; and African Americans are identified as emotionally/behaviorally disordered one and a half times as often as their white peers. The actual number of these &#8220;BD&#8221; (Behavioral Disorder) diagnoses has increased by 500% between 1974 and 1998.”</p>
<p>Dr. Eric Cooper, President of the National Urban Alliance notes how unfortunate it is that “misdiagnosis of special education status has been used to place a significant number of children of color into programs that doom them to a life of low expectations and low achievement.&#8221;</p>
<p>Professor Feuerstein agrees and writes that “Too often we give up on children who are labeled with learning disabilities, but my work has found that using more creative techniques to teach these children will lead them to the same successes that life offers the other children in the classroom. Poverty is not destiny and we can reverse major depression in a child&#8217;s cognitive development and realize impressive results.”</p>
<p>Feuerstein’s theory of Structural Cognitive Modifiability “views the human organism as open, adaptive and amenable for change. The aim of this approach is to modify the individual, emphasizing autonomous and self-regulated change. Intelligence is viewed as a propensity of the organism to modify itself when confronted with the need to do so. Intelligence is defined as a changeable state rather than an immutable trait.”</p>
<p>Feuerstein’s claim that “poverty is not destiny” and that we can improve a child&#8217;s cognitive development and realize impressive results is profoundly important. He asserts that the benefits to all of society cannot be overstated.</p>
<p>Let me give one example. It has been proposed by Dr. Paul Nussbaum that learning may act as a potential vaccine again Alzheimer’s Disease and other age-related neurodegenerative diseases of the brain.</p>
<p>If we begin to think of learning as a process that improves health, like nutrition and exercise, then all students need to maximize their cognitive development. If tens and hundreds of thousands of poor children are placed in programs that doom them to a life of low expectations and low achievement and learning does act as a vaccine against age-related neurodegenerative diseases of the brain, we are accelerating the rate of dementias.</p>
<p>Childhood poverty has already been linked to dementia. <a href="http://news.bbc.co.uk/2/hi/health/618356.stm" target="_blank">Author of the research, Dr Moceri</a>, said that &#8220;a poor quality childhood environment could prevent the brain from reaching a complete level of maturation.” The areas of the brain that show the earliest signs of Alzheimer&#8217;s are the one that take the longest time to mature during childhood and adolescence.</p>
<p>There are more than 5 million people in the United States living with Alzheimer’s. This means that every 72 seconds, someone develops Alzheimer’s. <a href="http://www.alz.org/alzheimers_disease_alzheimer_statistics.asp" target="_blank">The indirect costs of Alzheimer’s and other dementias amount to more than $148 billion annually</a>. Feuerstein’s International Center for the Enhancement of Learning works with children throughout the world. Plans are underway to start implementing the partnership in 20 U.S. cities. Educators, policy makers and journalists should follow the story carefully.</p>
<p>&#8211;Dr. Rohn Kessler</p>
<p><a href="http://sparksofgenius.com" target="_blank">CEO and Founder Sparks Of Genius</a></p>
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		<title>Brains Hardwired By Music?</title>
		<link>http://www.traumaticbraininjurycenters.com/2009/08/brains-hardwired-by-music/</link>
		<comments>http://www.traumaticbraininjurycenters.com/2009/08/brains-hardwired-by-music/#comments</comments>
		<pubDate>Sat, 08 Aug 2009 13:51:54 +0000</pubDate>
		<dc:creator>empower2go</dc:creator>
				<category><![CDATA[Brain and coping]]></category>
		<category><![CDATA[Research trends]]></category>
		<category><![CDATA[cognition and fibromyalgia]]></category>
		<category><![CDATA[music and cognition]]></category>
		<category><![CDATA[brain and music]]></category>
		<category><![CDATA[building memory strategies]]></category>
		<category><![CDATA[cancer new brain treatments]]></category>
		<category><![CDATA[cognition]]></category>
		<category><![CDATA[hardwired for music]]></category>
		<category><![CDATA[intellectual enhancement]]></category>
		<category><![CDATA[memory and ageing]]></category>
		<category><![CDATA[memory and music]]></category>
		<category><![CDATA[music and homework]]></category>
		<category><![CDATA[neuroscience and music]]></category>

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		<description><![CDATA[Our brains may be hardwired for music. Music enhances categorization skills and optimizes interbrain communication. Music can increase learning potential]]></description>
			<content:encoded><![CDATA[<div id="attachment_261" class="wp-caption alignright" style="width: 269px"><a rel="attachment wp-att-261" href="http://empower2go.wordpress.com/2009/08/08/brains-hardwired-by-music/baby-grand-piano-from-web-weaver-clip-art-2009/"><img class="size-medium wp-image-261 " title="Autobiographic Memory improved by Music" src="http://empower2go.files.wordpress.com/2009/08/baby-grand-piano-from-web-weaver-clip-art-2009.jpg?w=259" alt="Brains, Music  and Learning (Web Weaver Clip Art 2009) " width="259" height="300" /></a><p class="wp-caption-text">Brains, Music and Learning (Web Weaver Clip Art 2009) </p></div>
<p><strong>By Amy Price PhD</strong></p>
<p>In 2007 colleagues and I conducted a 42 participant study as part of a research school experiment on working memory and cognitive loading. We explored using music as a strategic intervention to alter working memory loads. The premise was music could aid in more effectual encoding to increase learning potential.  As we learn extraneous or intrinsic cognitive load is invoked. Extraneous working memory loading is experienced by learners as they interact with instructional materials. Intrinsic cognitive load is the inherent level of difficulty associated with instructional materials (Chandler and Sweller 1991). More learning cues such as using pictures as well as words, learning with a song or even allowing student’s hands on instruction helps decrease this load. The more unnecessary information it takes to deliver your point the more extraneous cognitive load is produced. This is where a picture is worth a thousand words!  (Ayres 2006) states that when intrinsic or extraneous cognitive load is high, working memory is overloaded and learning is adversely affected.</p>
<p>This process happens as we learn new skills that we later do with some automaticity such as driving, riding a bike, learning a musical instrument or even doing algebra. The forming of efficient categorization and schemas is called germane load (Paas et al 2003, Sweller et al 1998).  </p>
<p>We considered that since music aids in efficient categorization perhaps learning and music together could decrease cognitive loading and increase germane ability by lightening the load. We tested this by having participants first listen to music designed to entrain concentration. According to (Doman 2007) entrainment can occur in as little as one minute. Music with specific timbres and rhythmic structure has demonstrated an increase in effectual category formation, (Ostrander1994, Rose1997) and can aid visual spatial perception, (Ruvenshteyn and Parrino, 2005) (Orel, 2006) Music is shown to aid in hemispheric transfer or communication between both halves of the brain (Taut et al 2005). We felt participants in the auditory condition would increase germane load and decrease extraneous load. The decrease in extraneous load is expected because of the neuronal changes evoked by entrainment (Pouliot 1998) (Carter and Russel 1992)</p>
<p> What were our findings? Approximately 50% of our participants immediately increased their ability to sustain cognitive load by 150%. The other 50% decreased in this ability however many of these reported greater clarity of thought later in the day and improved their testing scores considerably. The lesson we learned from this is that for music to be effective at least for ½ the population consistency is the key. Many individuals need a consolidation period where learning is categorized and music is internalized.  </p>
<p>In fact, there are long term benefits of listening to music, notes Dan Levitin in This is Your Brain on Music.</p>
<p>“Music listening enhances or changes certain neural circuits, including the density of dendritic connections in the primary auditory cortex…The front portion of the corpus callosum—the mass of fibers connecting the two cerebral hemispheres—is significantly larger in musicians than non-musicians, and particularly for musicians who began their training early…Musicians tend to have larger cerebellums than non-musicians, and an increased concentration of grey matter…responsible for information processing.” In the end music is like exercise, starting later in life is better than not starting at all and may confer neuroprotective benefits…but that is another study!</p>
<p> </p>
<p>References</p>
<p>Ayres, P.L (2006) “Impact of reducing intrinsic cognitive load on learning in a mathematical domain”, Applied Cognitive Psychology, vol.20, 99 287-298.</p>
<p>Carter, J &amp; Russell H. (2002) A Pilot Investigation of Auditory and Visual Entrainment of Brain Wave Activity in Learning Disabled Boys Stanford University USA</p>
<p>Chandler, P. &amp; Sweller, J. (1991). &#8220;Cognitive Load Theory and the Format of Instruction&#8221;. Cognition and Instruction 8 (4): 293–332. doi:10.1207/s1532690xci0804_2. </p>
<p>Clark, R., Nguyen, F., and Sweller, J. (2006). Efficiency in Learning: Evidence-Based Guidelines to Manage Cognitive Load. San Francisco: Pfeiffer. ISBN 0-7879-7728-4. </p>
<p>Conway, A. R. A., Jarrold, C., Kane, M. J., Miyake, A., &amp; Towse, J. N. (Eds.). (2007). Variation in working memory. New York: Oxford University Press</p>
<p>Doman A, (2007) ABT conference Miami Fl. Advanced Brain Technology 5748 South Adams Avenue Parkway Ogden, Utah 84405, USA</p>
<p>Naish, P. 2005, Perceptual Processes ‘Attention’, Cognitive Psychology, Braisby and Gellatly, (eds) Open University in association with Oxford University Press UK</p>
<p>Orel, P., (2006) &#8216;Music Helps Students Retain Math&#8217;, Rutger’s Focus, Rutgers, The State University of New Jersey, New Jersey USA</p>
<p>Ostrander, S., Shroeder, L., and Ostrander, L. (1994) Super Learning New York, Delacorte Press, (1994)</p>
<p>Paas, F. Tuovinen, J., Tabbers, H., and Van Gerven, P., (2003) &#8216;Cognitive load measurement as a means to advance cognitive load theory&#8217;, Educational Psychologist, Vol 38(1), 63-71.</p>
<p>Pike and Edgar (2005) Perceptual Processes ‘Perception’, Cognitive Psychology, Braisby and Gellatly, (eds) Open University in association with Oxford University Press UK</p>
<p>Price A, Kessler R, 2006 &#8220;Sparks of Genius Recovered?&#8221;, Thinking Pays Boca Raton FL USA</p>
<p>Price A, Kirkpatrick M, Groszek M, “ 2007, Just practise? Or can ergonomic brain instruction or musical entrainment lighten the cognitive load to increase working memory performance and working load stamina?” Open University, Milton Keynes UK</p>
<p>Sweller et al (1988, 1989, 1993) Sweller, J., and Chandler, P., (1994) &#8216;Why some material is difficult to learn&#8217; Cognition and Instruction, vol.12, pp185-233.</p>
<p> Thaut, M., Peterson D., and McIntosh G. (2005) ‘Temporal Entrainment of Cognitive Functions: Musical Mnemonics Induce Brain Plasticity and Oscillatory Synchrony in Neural Networks Underlying Memory’, The Center for Biomedical Research in Music, Molecular, Cellular, and Integrative Neuroscience Programs, Colorado State University, Fort Collins, Colorado 80523, USA</p>
<p> Tomatis, A. (1991) The Conscious Ear, Station Hill Press, Paris, (1991)</p>
<p>Price A, Kessler R, 2006 &#8220;Sparks of Genius Recovered?&#8221;, Thinking Pays Boca Raton FL USA</p>
<p>Price A, Kirkpatrick M, Groszek M, “ 2007, Just practise? Or can ergonomic brain instruction or musical entrainment lighten the cognitive load to increase working memory performance and working load stamina?” Open University, Milton Keynes UK</p>
<p>Rose, C. &amp; Nicholl, M. (1997) Accelerating Learning for the 21st Century. New York: Dell Publishing (1997)</p>
<p>Roure, R., et al. (1998) Autonomic Nervous System Responses Correlate with Mental Rehearsal in Volleyball Training. Journal of Applied Physiology, 78(2), 99-108</p>
<p>  Ruvinshteyn M and Parrino L, (2005) Benefits Of Music In The Academic Classroom</p>
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		<title>Memory and Music Connections</title>
		<link>http://www.traumaticbraininjurycenters.com/2009/08/memory-and-music-connections/</link>
		<comments>http://www.traumaticbraininjurycenters.com/2009/08/memory-and-music-connections/#comments</comments>
		<pubDate>Mon, 03 Aug 2009 06:01:05 +0000</pubDate>
		<dc:creator>empower2go</dc:creator>
				<category><![CDATA[Brain Help]]></category>
		<category><![CDATA[Brain and coping]]></category>
		<category><![CDATA[Research trends]]></category>
		<category><![CDATA[brain fog]]></category>
		<category><![CDATA[brain potential]]></category>
		<category><![CDATA[building memory strategies]]></category>
		<category><![CDATA[cognitive help]]></category>
		<category><![CDATA[memory and ageing]]></category>

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		<description><![CDATA[This latest research could explain why even Alzheimer's patients who endure increasing memory loss can still recall songs from their distant past. It is thought that medial portion of the prefrontal cortex is less susceptible to atrophy]]></description>
			<content:encoded><![CDATA[<div id="attachment_240" class="wp-caption alignright" style="width: 310px"><a rel="attachment wp-att-240" href="http://empower2go.wordpress.com/2009/08/03/memory-and-music-connections/medial-prefrontal-cortex-music-2/"><img class="size-medium wp-image-240" title="Medial PreFrontal Cortex MUsic" src="http://empower2go.files.wordpress.com/2009/08/medial-prefrontal-cortex-music1.png?w=300" alt="Brain, Music and Memory (Dr Janata 2009)" width="300" height="216" /></a><p class="wp-caption-text">Brain, Music and Memory (Dr Janata 2009)</p></div>
<div id="attachment_237" class="wp-caption alignleft" style="width: 183px"><a rel="attachment wp-att-237" href="http://empower2go.wordpress.com/2009/08/03/memory-and-music-connections/medial-prefrontal-cortex-music/"><img class="size-medium wp-image-236" title="IPOD for Alzheimers" src="http://empower2go.files.wordpress.com/2009/08/ipod-for-alzheimers.png?w=173" alt="Music For Brain Enhancement" width="173" height="300" /></a><p class="wp-caption-text">Brain on Music (Dr Janata)</p></div>
<p><strong>By Amy Price PhD</strong></p>
<p>We have found in our practice that music can trigger powerful memories even for people that have sustained brain damage and have lost the ability to speak. Sometimes stroke or TBI victims can sing fluently because the path to music is stored in a different area of the brain than the one used for recalling words. As a culture we understand the power of music and now a brain-scan study reveals where music makes its mark.<br />
The part of the brain music activates is known as the medial pre-frontal cortex and sits just behind the forehead. &#8220;What seems to happen is that a piece of familiar music serves as a soundtrack for a mental movie that starts playing in our head.&#8221; said Dr. Janata, a cognitive neuroscientist at University of California, Davis. &#8220;It calls back memories of a particular person or place, and you might all of a sudden see that person&#8217;s face in your mind&#8217;s eye.&#8221;<br />
Janata noticed the medial pre-frontal cortex showing the same kind of activity when In Janata’s study this area responded quickly to music rhythm and chord changes, but also reacted when tunes were autobiographically relevant. In addition music provoked the strongest activity in the brain when it was combined with autobiographical memories.</p>
<p>This latest research could explain why even Alzheimer&#8217;s patients who endure increasing memory loss can still recall songs from their distant past. It is thought that medial portion of the prefrontal cortex is less susceptible to atrophy according to Janata.<br />
Music does not cure Alzheimer&#8217;s or fix TBI but can help patients recover precious memories, help with thought organization and improve quality of life.<br />
Maybe the Apple a day for Alzheimer’s is the IPOD. Dr. Janata has a project underway to make that happen</p>
<p><strong>References:</strong>• Janata, P. The neural architecture of music-evoked autobiographical memories. Cerebral Cortex. Advance Access published February 24, 2009, doi:10.1093/cercor/bhp008. For supplementary information, go to the Advance Access page and search for the article.<br />
• Janata, P., Tomic, S. T., &amp; Rakowski, S. K. (2007). Characterization of music-evoked autobiographical memories. Memory, 15(8), 845–860.</p>
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		<title>Cerebral Palsy, Stem Cell Banking, and Success</title>
		<link>http://www.traumaticbraininjurycenters.com/2009/07/cerebral-palsy-stem-cell-banking-and-success/</link>
		<comments>http://www.traumaticbraininjurycenters.com/2009/07/cerebral-palsy-stem-cell-banking-and-success/#comments</comments>
		<pubDate>Sun, 05 Jul 2009 15:13:15 +0000</pubDate>
		<dc:creator>empower2go</dc:creator>
				<category><![CDATA[Brain Help]]></category>
		<category><![CDATA[Cerebral Palsy]]></category>
		<category><![CDATA[Research trends]]></category>
		<category><![CDATA[cord banking]]></category>
		<category><![CDATA[80% improvement in Parkinson's with adult stem cells]]></category>
		<category><![CDATA[adult stem cells]]></category>
		<category><![CDATA[Cerebral Palsy stem cell cure]]></category>
		<category><![CDATA[donating stem cells]]></category>
		<category><![CDATA[FDA and stemcells]]></category>
		<category><![CDATA[stem cells and China]]></category>

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		<description><![CDATA[Brain injury, Spinal Cord Damage and Cerebral Palsy are demonstrating success with patients own stem cells. Research for AIDS, MS and Sickle cell using donor cells are increasing. Public and Private cell banking facilities demand a choice, share with others or keep your own for a time of need?]]></description>
			<content:encoded><![CDATA[<div id="attachment_191" class="wp-caption alignleft" style="width: 160px"><a href="http://www.msnbc.msn.com/id/21134540/vp/23569985#23569985"><img class="size-full wp-image-191   " title="dallas_baby" src="http://empower2go.files.wordpress.com/2009/07/dallas_baby1.jpg" alt="Dallas Hextell Foundation 2009 for video click link" width="150" height="150" /></a><p class="wp-caption-text">Dallas Hextell Foundation 2009 for video click Picture</p></div>
<div><a title="Dallas Cord Blood Story" href="http://www.msnbc.msn.com/id/21134540/vp/23569985#23569985" target="_blank"></a></div>
<div><a title="Dallas Cord Blood Story" href="http://www.msnbc.msn.com/id/21134540/vp/23569985#23569985" target="_blank"></a></div>
<p><a title="Dallas Cord Blood Story" href="http://www.msnbc.msn.com/id/21134540/vp/23569985#23569985" target="_blank"></p>
<div class="mceTemp"><strong>By Amy Price PhD</strong></div>
<p> </p>
<p> </p>
<p></a></p>
<p>Brain injury, Spinal Cord Damage and Cerebral Palsy are demonstrating success with patients own stem cells. Research for AIDS, MS and Sickle cell using donor cells are increasing. Public and Private cell banking facilities demand a choice, share with others or keep your own for a time of need?</p>
<p><a title="When medicine meets marketing" href="http://www.msnbc.msn.com/id/21134540/vp/23569985#23569985" target="_blank">Mary Carmichael of Newsweek did a compelling interview </a>with a couple whose young son was diagnosed with cerebral palsy and the doctor who conducted the experimental treatment. She outlines the medicine for profit aspect of stemcell storage. The pathos of the doctors comments that he may have gotten better anyway and the soft sell for public banking yet raise interesting points. My children are  adults but even in the early years their cord blood was collected and donated for research.</p>
<p> The Hextell&#8217;s featured in the video above tried to conceive for three years and finally with invitro fertilization succeeded. Little Dallas was born wanted and celebrated into a medicine savvy family who banked his own cord blood cells. Dallas was diagnosed with cerebral palsy and became one of the privileged children chosen for research at Duke university. If my children had Cerebral Palsy they could not have enjoyed this benefit because the cells were given for others and presonal access was unavailable.  I would propose a two tier system where cells could be banked for public use but accessed in case of physical need by the donor providing cells were still available.</p>
<p>This is the way we prepared for my husbands bilateral hip replacement. We arranged to have blood taken in advance and then agreed if it was not needed it would go into the public bank. It turns out he needed his blood and then some which made me feel the power of the donations  of all the blood and platelets we have supplied over the years as a family. Some conditions require more cells than the cord blood can grow and others have genetic variables that would make using someone else&#8217;s cord cells  more viable.</p>
<p>I am blogging on this because I recieve requests from parents asking if they should take their children to China in hope of a cure.  Research in the USA and from animals studies show about a 30% improvement rate. Opponents and researchers agree that only 1-2% of the cells get to the brain when delivered intravenously, however it may be other components in the cell that are acting to faciliate repair and recovery.  I will blog an answer from my perspective in a future blog</p>
<p>For this post here are some links on cord banking</p>
<p><a href="http://www.newsweek.com/id/174276" target="_blank">Private or Public Banking?</a></p>
<p><a href="http://parentsguidecordblood.org/" target="_blank">Parent&#8217;s Giude to Cord Banking</a></p>
<p><a href="http://www.marrow.org/HELP/Donate_Cord_Blood_Share_Life/Cord_Blood_Donation_FAQs/index.html#needed" target="_blank">Be The Match</a></p>
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		<title>Junk DNA gets a voice</title>
		<link>http://www.traumaticbraininjurycenters.com/2009/06/junk-dna-gets-a-voice/</link>
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		<pubDate>Sun, 28 Jun 2009 03:34:33 +0000</pubDate>
		<dc:creator>empower2go</dc:creator>
				<category><![CDATA[DNA]]></category>
		<category><![CDATA[Research trends]]></category>
		<category><![CDATA[Uncategorized]]></category>
		<category><![CDATA[adult stem cells]]></category>
		<category><![CDATA[FDA and stemcells]]></category>
		<category><![CDATA[Genes]]></category>
		<category><![CDATA[junk DNA]]></category>
		<category><![CDATA[neural plasticity]]></category>
		<category><![CDATA[regenerative medicine]]></category>
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		<guid isPermaLink="false">http://empower2go.wordpress.com/?p=155</guid>
		<description><![CDATA[By Amy Price PhD   Not so many years ago we were told as students that a very small part of the genome coded for genes and the rest was &#8216;Junk DNA&#8221;. The questions why? followed by what if  come quickly when I am faced with such literal statements. The answer they are junk because no one [...]]]></description>
			<content:encoded><![CDATA[<p><strong></p>
<div id="attachment_156" class="wp-caption alignleft" style="width: 157px"><a rel="attachment wp-att-156" href="http://empower2go.wordpress.com/2009/06/28/junk-dna-gets-a-voice/junkdna-crystallinks-com-2009/"><img class="size-medium wp-image-156  " title="junkdna Crystallinks.com 2009" src="http://empower2go.files.wordpress.com/2009/06/junkdna-crystallinks-com-2009.jpg?w=300" alt="  &quot;Junk DNA&quot;  Courtesy Crystal Links.com 2009" width="147" height="128" /></a><p class="wp-caption-text">&quot;Junk DNA&quot; Courtesy Crystal Links.com 2009</p></div>
<p>By Amy Price PhD</p>
<p></strong></p>
<p> </p>
<p>Not so many years ago we were told as students that a very small part of the genome coded for genes and the rest was &#8216;Junk DNA&#8221;. The questions why? followed by what if  come quickly when I am faced with such literal statements. The answer they are junk because no one knows what they do brought cause for alarm in my view because I don&#8217;t know what a good portion of the human race does  yet I would not relegate them to junk. I countered with I want to know what happened when you took them all out&#8230;turns out that was not doable and I was relegated to the divergent thinker category and lectured on the KISS (Keep It Simple Stupid) principle.</p>
<p>I later found a few people such as McClintock who saw this DNA may have value in the 1940s and worked tirelessly  to explore the DNA as a regulatory source for determining which genes are turned on and when they were activated (McClintock, 1965) Around the same time  Britten and  Davidson agreed and further  speculated the junk DNA plays a role in generating different <span>cell</span> types and different biological structures, depending on where in the <span>genome</span> they insert themselves (Britten &amp; Davidson, 1969).</p>
<p>Recently, scientists from Princeton  and Indiana Universities studied the genome of a pond organism and found  that junk DNA or transposons may perform functions that are central to the existence of an organism. Apparently  these genes jump from location to location rearranging  the genome in a way that initiates growth just as McClintock thought. </p>
<p>These genes are labelled transposons. In and during development, the transposons appear to first influence hundreds of thousands of DNA pieces to regroup. Then, when they are no longer needed the organism can erase the transposases from its genetic material, paring its genome to about 5 percent of its original load.</p>
<p>&#8220;The transposons actually perform a central role for the cell,&#8221; said <a href="http://www.princeton.edu/eeb/people/display_person.xml?netid=lfl&amp;display=Faculty" target="_self">Laura Landweber</a>, a professor of <a href="http://www.princeton.edu/eeb/" target="_self">ecology and evolutionary biology</a>at Princeton and an author of the study. &#8220;They stitch together the genes in working form.&#8221; This research  appeared in the May 15 edition of Science. (MacPherson, Princeton, 2009)</p>
<p>We are just now finding the science that existed in the mind of a researcher over sixty years ago and can watch revelation unravel as  science begins to explore how extensive the role of  junk  or as sometimes coined selfish DNA plays in  the circle of life&#8230;.Sometimes just as in life it is those quietly working without accolades that are holding it all together who are the real stars!<br />
Britten, R. J., &amp; Davidson, E. H. Gene regulation for higher cells: A theory. <em>Science </em><strong>165</strong>, 349–357 (1969)</p>
<p> McClintock, B. Components of action of the regulators Spm and Ac. <em><em>Carnegie Institution</em></em><strong><em> </em></strong><em>of <em><em>Washington</em></em> Year Book </em><strong>64</strong><em>,</em> 527–536 (1965)</p>
<p>MacPherson ,2009 <a href="http://www.princeton.edu/main/news/archive/S24/28/32C04/">http://www.princeton.edu/main/news/archive/S24/28/32C04/</a> accessed june 27, 2009)</p>
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		<title>Brain pills? Piracetam Shows Promise</title>
		<link>http://www.traumaticbraininjurycenters.com/2009/05/a-pill-for-memory-piracetam-revisited-2/</link>
		<comments>http://www.traumaticbraininjurycenters.com/2009/05/a-pill-for-memory-piracetam-revisited-2/#comments</comments>
		<pubDate>Sun, 17 May 2009 15:10:00 +0000</pubDate>
		<dc:creator>empower2go</dc:creator>
				<category><![CDATA[Brain Help]]></category>
		<category><![CDATA[Brain and coping]]></category>
		<category><![CDATA[Research trends]]></category>
		<category><![CDATA[chronic pain and TBI]]></category>
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		<category><![CDATA[Priacetam]]></category>
		<category><![CDATA[regenerative medicine]]></category>
		<category><![CDATA[working memory improvement]]></category>

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		<description><![CDATA[By Amy Price PhD One significant problem in traumatic brain injury is that secondary cell death occurs when the injured cells block the path for the other cells to get oxygen. One product that is used extensively in other countries but not the USA is Piracetam. It is interesting that research in pub med is [...]]]></description>
			<content:encoded><![CDATA[<p><strong>By Amy Price PhD</strong></p>
<div><a href="http://1.bp.blogspot.com/_xf3dZ_ICe2c/ShAxv0HnqgI/AAAAAAAAACY/PF4nNSbb1P8/s1600-h/Piracetam.png"><img style="width:320px;float:left;height:246px;cursor:hand;margin:0 10px 10px 0;" src="http://1.bp.blogspot.com/_xf3dZ_ICe2c/ShAxv0HnqgI/AAAAAAAAACY/PF4nNSbb1P8/s320/Piracetam.png" border="0" alt="" /></a></div>
<div>One significant problem in traumatic brain injury is that secondary cell death occurs when the injured cells block the path for the other cells to get oxygen. One product that is used extensively in other countries but not the USA is <span class="blsp-spelling-error">Piracetam</span>. It is interesting that research in pub med is showing promise for efficacy in human trials. There have been rat, rabbit, and fruit fly trials available for years but there is a lot that can differ between these and seeing actual human benefit.</div>
<div>I used this product to good effect many years ago without side effects and am encouraged to see studies supporting its effectiveness. The alternatives available to many people with <span class="blsp-spelling-error">TBI</span> as far as psychotropic <span class="blsp-spelling-error">meds</span> to restore some measure of function are concerned can sometimes have unexpected reactions or be of no effect.</div>
<div><span class="blsp-spelling-error">Piracetam</span> has been shown to alter the physical properties of the plasma membrane by increasing its fluidity and by protecting the cell against hypoxia. It increases red cell <span class="blsp-spelling-error">deformability</span> and normalizes aggregation of hyperactive platelets according to <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;Cmd=Search&amp;Term=%22Winnicka%20K%22%5BAuthor%5D&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><span class="blsp-spelling-error">Winnicka</span> K</a>, <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;Cmd=Search&amp;Term=%22Tomasiak%20M%22%5BAuthor%5D&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><span class="blsp-spelling-error">Tomasiak</span> M</a>, <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;Cmd=Search&amp;Term=%22Bielawska%20A%22%5BAuthor%5D&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><span class="blsp-spelling-error">Bielawska</span> A</a> (2005) They are saying treatment with <span class="blsp-spelling-error">piracetam</span> improves learning, memory, brain metabolism, and capacity by the interaction of this molecule with the membrane <span class="blsp-spelling-error">phospholipids</span> to restore membrane fluidity . The graph below is from smart publications</div>
<div><a href="http://2.bp.blogspot.com/_xf3dZ_ICe2c/ShAyBV8ShWI/AAAAAAAAACg/hxOvwjuRiE8/s1600-h/smartpublications.gif"><img style="width:320px;float:left;height:255px;cursor:hand;margin:0 10px 10px 0;" src="http://2.bp.blogspot.com/_xf3dZ_ICe2c/ShAyBV8ShWI/AAAAAAAAACg/hxOvwjuRiE8/s320/smartpublications.gif" border="0" alt="" /></a></div>
<div>The positive therapeutic effects of <span class="blsp-spelling-error">piracetam</span> on cognitive (memory, attention, executive functions) and motor (coordination) functions as well as the speed of cognitive and motor performance were demonstrated in a study done by <a href="AL_get(this,"><span class="blsp-spelling-error">Zh</span> <span class="blsp-spelling-error">Nevrol</span> <span class="blsp-spelling-error">Psikhiatr</span> <span class="blsp-spelling-error">Im</span> S S <span class="blsp-spelling-error">Korsakova</span>.</a> 2008 for adolescents who sustained <span class="blsp-spelling-error">TBI&#8217;s</span>.</div>
<div>Its efficacy is documented in cognitive disorders and dementia, vertigo, cortical <span class="blsp-spelling-error">myoclonus</span>, dyslexia, and sickle cell anemia according to <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;Cmd=Search&amp;Term=%22Winblad%20B%22%5BAuthor%5D&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><span class="blsp-spelling-error">Winblad</span> B</a> (2005).</div>
<div>The results of a meta-analysis <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;Cmd=Search&amp;Term=%22Waegemans%20T%22%5BAuthor%5D&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><span class="blsp-spelling-error">Waegemans</span> T</a>, <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;Cmd=Search&amp;Term=%22Wilsher%20CR%22%5BAuthor%5D&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><span class="blsp-spelling-error">Wilsher</span> CR</a>, <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;Cmd=Search&amp;Term=%22Danniau%20A%22%5BAuthor%5D&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><span class="blsp-spelling-error">Danniau</span> A</a>, <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;Cmd=Search&amp;Term=%22Ferris%20SH%22%5BAuthor%5D&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus">Ferris SH</a>, <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;Cmd=Search&amp;Term=%22Kurz%20A%22%5BAuthor%5D&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><span class="blsp-spelling-error">Kurz</span> A</a>, <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;Cmd=Search&amp;Term=%22Winblad%20B%22%5BAuthor%5D&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><span class="blsp-spelling-error">Winblad</span> B</a>. (2002) demonstrate a difference between those individuals treated with <span class="blsp-spelling-error">piracetam</span> and those given placebo, both as significant odds ratio and as a favourable number needed to treat. While there may be problems in meta-analyses and the interpretation of the statistical results, the results of this analysis provide compelling evidence for the global efficacy of <span class="blsp-spelling-error">piracetam</span> in a diverse group of older subjects with cognitive impairment.</div>
<div>This post does not in any way constitute any medical advice or recommendation. These posts are educational only to share with others some of the direction research is taking. Any medical information gained online should be supported and endorsed by your own doctor.</div>
<div><strong>References:</strong></div>
<div><a href="http://www.ncbi.nlm.nih.gov/pubmed/18427539?ordinalpos=1&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">[The consequences of closed traumatic brain injury and <span class="blsp-spelling-error">piracetam</span> efficacy in their treatment in adolescents]</a><br />
<span class="blsp-spelling-error">Zavadenko</span> <span class="blsp-spelling-error">NN</span>, <span class="blsp-spelling-error">Guzilova</span> LS.<br />
<span class="blsp-spelling-error">Zh</span> <span class="blsp-spelling-error">Nevrol</span> <span class="blsp-spelling-error">Psikhiatr</span> <span class="blsp-spelling-error">Im</span> S S <span class="blsp-spelling-error">Korsakova</span>. 2008;108(3):43-8. Russian.<br />
<span class="blsp-spelling-error">PMID</span>: 18427539 [<span class="blsp-spelling-error">PubMed</span> - indexed for <span class="blsp-spelling-error">MEDLINE</span>]<br />
<a class="status_ra" href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&amp;cmd=link&amp;linkname=pubmed_pubmed&amp;uid=18427539&amp;ordinalpos=1:">Related Articles</a></div>
<div><a href="http://www.ncbi.nlm.nih.gov/pubmed/16459490?ordinalpos=4&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum"><span class="blsp-spelling-error">Piracetam</span>&#8211;an old drug with novel properties?</a><br />
<span class="blsp-spelling-error">Winnicka</span> K, <span class="blsp-spelling-error">Tomasiak</span> M, <span class="blsp-spelling-error">Bielawska</span> A.<br />
<span class="blsp-spelling-error">Acta</span> Pol <span class="blsp-spelling-error">Pharm</span>. 2005 Sep-Oct;62(5):405-9. Review.<br />
<span class="blsp-spelling-error">PMID</span>: 16459490 [<span class="blsp-spelling-error">PubMed</span> - indexed for <span class="blsp-spelling-error">MEDLINE</span>]<br />
<a class="status_ra" href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&amp;cmd=link&amp;linkname=pubmed_pubmed&amp;uid=16459490&amp;ordinalpos=4:">Related Articles</a></div>
<div><a href="http://www.ncbi.nlm.nih.gov/pubmed/16007238?ordinalpos=5&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum"><span class="blsp-spelling-error">Piracetam</span>: a review of pharmacological properties and clinical uses.</a><br />
<span class="blsp-spelling-error">Winblad</span> B.<br />
CNS Drug Rev. 2005 Summer;11(2):169-82. Review.<br />
<span class="blsp-spelling-error">PMID</span>: 16007238 [<span class="blsp-spelling-error">PubMed</span> - indexed for <span class="blsp-spelling-error">MEDLINE</span>]<br />
<a class="status_ra" href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&amp;cmd=link&amp;linkname=pubmed_pubmed&amp;uid=16007238&amp;ordinalpos=5:">Related Articles</a></div>
<div><a href="http://www.ncbi.nlm.nih.gov/pubmed/12006732?ordinalpos=7&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">Clinical efficacy of <span class="blsp-spelling-error">piracetam</span> in cognitive impairment: a meta-analysis.</a><br />
<span class="blsp-spelling-error">Waegemans</span> T, <span class="blsp-spelling-error">Wilsher</span> CR, <span class="blsp-spelling-error">Danniau</span> A, Ferris SH, <span class="blsp-spelling-error">Kurz</span> A, <span class="blsp-spelling-error">Winblad</span> B.<br />
<span class="blsp-spelling-error">Dement</span> <span class="blsp-spelling-error">Geriatr</span> <span class="blsp-spelling-error">Cogn</span> <span class="blsp-spelling-error">Disord</span>. 2002;13(4):217-24.<br />
<span class="blsp-spelling-error">PMID</span>: 12006732 [<span class="blsp-spelling-error">PubMed</span> - indexed for <span class="blsp-spelling-error">MEDLINE</span>]<br />
<a class="status_ra" href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&amp;cmd=link&amp;linkname=pubmed_pubmed&amp;uid=12006732&amp;ordinalpos=7:">Related Articles</a></div>
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