Brain Training You Can do Together

By Amy Price PhD 

    Do you need to get your life back and restore relationships after trauma? It is not only truama survivors that can benefit from training but also family and caregivers who deal with the unexpected pressure of caring for a critically injured loved one. Brain neurons that fire together wire together, families that play together, stay together! Extensive research indicates our brain needs to overcome the negativity bias ingrained through the fight/flight response produced by trauma or social rejection to operate at maximum potential. It is more than positive thinking as the mind has a specific ratio of positive to negative input it accepts plus the input must be genuine to release the feel good chemicals that promote brain learning and healing.  Many people involved in an auto crash must fight for insurance rights and social acceptance during an era of limited capacity and chronic pain. All these aspects take a critical toll on the brain and promote inflammation cascades that lead to long term functional loss. The great news is that with targeted brain training in small manageable steps you can get back the edge taken from you though trauma, bad relationships, or serious illness. Your brain wants to work for you! 

Clicking on Train Your Brain , Save Your Mind here will take you to a fascinating short video on the power of personal brain optimization and contains a clinically validated assessment tool. This video is presented by Dr Evian Gordon of Brain Resource Company  and speaks about the highly acclaimed wellness program My Brain Solutions. It is well worth investigating, in less than 15 days I showed improvement on several measures of cognition. If you would like to sign-up for MyBrainSolutions please email me ….read on for why training your brain matters. 

Our minds and brains become so starved for approval and acceptance that we accept input and relationships that are harmful and not genuine. Your own brain even when it is damaged can pick up emotional cues in 1/20 of a second  which will determine how we respond to others.  I worked for the medical director of an organization for several years following a TBI…it was not until I was past that situation and had embarked on an adventure training positive emotions that I realised that in four years I had never been given a genuine smile. How can you tell? For a smile ask your self if the eyes crinkle slightly and the pupils enlarge, smiling with only the mouth is not genuine expression. Interestingly this insight has been validated by multiple behavioral, FMRI, GSR and QEEG studies, yet like many insights it is rooted in wisdom passed down from successful individuals who are at peace with themselves. Dr David Whitehouse, an eminent Harvard trained Psychiatrist put is this way  ”PEOPLE NOT ONLY SEEK AN EMPOWERING MIND, BUT ONE THAT IS AT PEACE WITH ITSELF”.  My Brain Solutions can help you learn to discern emotion and train your brain from a negative to a positive bias and offers a clinically validated personal assessment with a presonalized prescription to increase your brain function. Dr Evian Gordon states in his book ‘The Brain Revolution’ that  “THE DIFFERENCE BETWEEN AND EXPERT AND A NOVICE LEARNER IS A MODEL” One critical component of cognitive skill is one’s ability to speedily reframe or re-appraise the circumstances that surround you. People that successfully reframe have better life satisfaction and long term survival rates than those who are fixated on negative events, this ability can be trained. 

Research on cognition that shows transfer of training and increase in quality of life is dependent on carefully assessing individual differences with  clinically accepted tools which provide personalized training to meet these perimeters[1,2,3,4,] 

Learning and novelty are partners yet many brain fitness programs offer rote repetition of weak areas without variation in task or content in a bid to target learning, However research shows us this is not the way meaningful learning occurs. Tasks must be individually challenging to hold engagement and yet structured enough to be doable. Ideally tasks will adapt to changing learning curves to build neuroplasticity. The best learning capitalizes on emotional and intellectual strengths already present while strengthening areas of weakness in a positive atmosphere. For example, teaching a university student mnemonics and concept mapping may make the memory more efficient however teaching an individual with organic damage or early dementia how to remember names and faces with a mnemonic is an exercise in futility. 

Specific training alone can lead to plastic changes in the brain as demonstrated by expert Braille readers who show an enlarged hand area and smearing of finger representations in the somatosensory cortex. This result was observed in expert, but not in novice Braille readers suggesting that the training and not the blindness which leads to the changes in cortical representation [5]Similar domain specific results were noted in London taxi drivers and expert violinists. Kramer et al [6] states recruitment of additional brain regions helps performance only if the recruited area complements processing of the task in question. This is likely why rote memorization fails to increase working memory whereas training that targets attentional networks and processing speed increases working memory limits. We are incapable of processing in depth what we have not attended to and our capacity for material attended to is limited by the speed at which we process stimuli. 

References: 

1. Posner, M., & Rothbart M. Educating the human brain. Washington, DC US: American Psychological Association.; 2007:189-208. doi:10.1037/11519-009 

2. Jaeggi SM, Buschkuehl M, Jonides J, Perrig WJ. Improving fluid intelligence with training on working memory. Proceedings of the National Academy of Sciences of the United States of America. 2008;105(19):6829-33. Available at: http://www.ncbi.nlm.nih.gov/pubmed/18443283 

3. Willis SL, Tennstedt SL, Marsiske M, et al. Long-term effects of cognitive training on everyday functional outcomes in older adults. JAMA : the journal of the American Medical Association. 2006;296(23):2805-14. Available at: http://www.ncbi.nlm.nih.gov/pubmed/17179457 

4. Gordon E, Arns M, Paul RH. Research Report THE INTEGRATE MODEL OF EMOTION, THINKING AND SELF REGULATION: AN APPLICATION TO THE “PARADOX OF AGING”. Thinking. 2008;7(3):367-404. 

5. Greenwood PM. Functional plasticity in cognitive aging: review and hypothesis. Neuropsychology. 2007;21(6):657-73. http://www.ncbi.nlm.nih.gov/pubmed/17983277 

6. Kramer AF, Bherer L, Colcombe SJ, Dong W, Greenough WT. Environmental influences on cognitive and brain plasticity during aging. The journals of gerontology. Series A, Biological sciences and medical sciences. 2004;59(9):M940-57.: http://www.ncbi.nlm.nih.gov/pubmed/15472160

Predictive medicine can change our tomorrows today. Regenerative medicine can replace artificial body parts with lab grown technologies while genetic breakthroughs can save families from generations of genetic disability. It is possible that new knowledge of human genetics and cell biology is likely to transform medical practice. Three likely scenarios could evolve:

•Genetics will lead to the classification of diseases on the basis of the underlying genetics or biochemistry, rather than by symptoms alone leading to preventive rather than crisis orientated treatments.
•Genetic information will identify people who are likely to respond to drugs, or to be harmed by them (pharmacogenetics). This is already possible with certain psychotropic drugs on an experimental level but has not trickled down into mainstream medicine.
•Genetic variation will be a new ‘susceptibility factor’, permitting monitoring and early treatment or, perhaps prevention, of an increasing proportion of common, multifactorial diseases, such as coronary heart disease, hypertension, stroke, cancer, diabetes and Alzheimer’s disease. Even stress management can be amplified with knowledge of individual genotypes

It is the genetic variation susceptibility factor which is considered to be the change maker for the advent of predictive medicine. This could lead to regenerative medicine on a cellular (somatic) level or even in vitro gene manipulation (germ line therapy) which could prevent intergenerational transfer of genetic disabilities.
Predictive medicine, when it comes, will be based on a much wider use of genetic testing, at present the gap between what the healthcare system is geared up and trained to deliver and what is scientifically viable is huge. For example there are treatments approved for traumatic brain injury that are effective but most be given within a couple of hours of trauma. This can’t happen now because emergency room personnel are not adequately trained or equipped to diagnose MTBI… As with any new technology applied to health in the context of a complex delivery system, implementation is not going to be simple.

First, of course, there needs to be demand from medical personnel and the general public. Typically wide spread change will only take place after the following criteria are established:

•Demonstration of clinical effectiveness and patient safety – through statistically valid clinical trials
•Cost-effective for general use – through economic analysis of trials and other data;
•Standardization of technology, and quality control – generally through outside regulation of suppliers and laboratories;
•Allocation of resources;
•Recruitment and education and training (or retraining) for health workers – including specialists, MDs, nurses, counselors and technicians. For instance a surgeon who makes a good living performing spinal fusions and cervical repairs will need significant convincing, retraining and motivation to become an early adopter of treatment that makes the previous way of doing business obsolete.

Predictive, regenerative medicine may be the wave of the future. History teaches us that the way to greatness is to find a way to serve many. My dream is to witness a generation of scientists and medical professionals join in unity with a foundation of integrity to build a tomorrow for the patients and public who have make their careers possible.

References:

Materials adapted from Open University Course Materials (accessed july,2009)

With spinal injuries and head injuries it is often the secondary damage to the neurons that causes big problems especially when that swelling and inflammation is in the spinal cord or the brain. The worst damage shows up several hours to many days later. Now, scientists in Rochester, New York, have discovered a simple way to stop a lot of this secondary damage in its tracks…at least in mice by using that old familiar blue food dye that gives M&Ms, blue bubble gum and blue raspberry popsicles their color. Patients with spinal injuries could escape with vastly reduced loss of function if this works in people but they’ll turn bright blue in the process.

Much secondary damage is caused by adenosine triphosphate, or ATP. This chemical can go into overkill with trauma and cause neurons to fire until they burn out and die leaving inflammation and sludge to trip up the neurons behind them causing an unhealthy destructive cycle. With spinal trauma, the area around the injury is flooded with ATP, which causes otherwise healthy neurons to fire out of control until they die of exhaustion. It also increases the swelling around the wound. Swelling around an injury site is a positive healing factor in many parts of the body, but because the spinal cord is encased in a narrow column blood supply gets cut off and cells die. But a study published in July 28′s Proceedings of the National Academy of Sciences (PNAS) seems to show that it’s possible to block the actions of ATP and greatly reduce the severity and permanence of spinal injuries – using the same type of food dye that gives blue M&Ms their color, a food dye called Brilliant Blue G, or BBG.

BBG can be administered intravenously with no need to inject directly into the injury site. It has the ability to cross the blood-brain barrier, which then gives it access to the spinal cord. BBG binds to the same neuroreceptor (P2X7) as the ATP binds to but it has a stronger affinity for the receptor than ATP has and gets there first so it effectively blocks the action of the ATP at the injury site.
Only one problem….patients turn blue ! It is temporary and is sure better than having a serious injury. You wear the injury but the blue die wears off…..All I can say is color me blue for spinal injury.

See the full method of the experiments here (PDF). BBG has been a food dye approved by the FDA since the 1920s but would this be considered off label use like the cholesterol lowering of Cheerios cereal. While all the rats were severely injured, the BBG-injected rats showed a greatly improved ability to support their bodyweight on their hind legs, control their bladders, and even walk in some cases. The blue skin coloring eventually faded as well, and no side effects were noted.

Human testing would be required before BBG can be moved forward into clinical use. It would be a terrific tool for ambulance drivers and paramedics. They could begin treatment right at the site of the incident, It is cheap and easy, even hospitals can use the blue stuff as soon as they get the patient hooked up and ready to go.

The kids must have known best when they told me blue ice cream was good for me …As for me…I will stock up on blue Gatorade and drink it down just in case it could make a difference!

By Amy Price PhD

There is some information on the internet declaring Alzheimers is more common in people who take NSAIDS. I have watched people do things like take vicodin instead of an antiinflammatory or discontinue baby aspirin therapy suggested by a cardiologist to deal with sticky platelets. Some will not take an antiinflammatory because bone fractures don’t heal as well if one is simultaneously taking this class of medication.

Getting drug addicted,setting up the CNS for chronic pain sensitivity by not treating inflammation,or letting excess platelet aggregation continue doesn’t help cognition either and in may ultimately set you up for the very condition you are trying to avoid.

There is research reporting specific use of antiinflammatory agents may reduce Alzheimers. It could be chronic pain and inflammation that aggravate loss of cognition rather than the NSAIDS taken to alleviate the symptoms.

There are many cardiac patients who took part in a Canadian study 25 years ago. They were encouraged to take a baby aspirin, vitamin C, and calcium buffered with vitamins K and D rather than be placed on beta blockers and more heavy duty cardiac meds. For many of these individuals this regimen solved the problem.

Drug addiction doesn’t always come from illegal street drugs. There are multitudes who became addicted just trying to stop the long term pain. These drugs work by altering nerve and brain messengers and overtime this leads to imbalance in the way the brain works.
As for the bones? Studies show that in eostrogen deficient or aged persons aspirin use may protect bone density. Research also shows fracture healing can be slowed by antiinflammatory use but this effect is temporary and if you stop taking them the fracture will heal at a normal rate.

In conclusion it is all about balance…

“The procedure is totally simple and cheap,” reports UNSW’s Dr Nick Di Girolamo (lead author of research study), “Unlike other techniques, it requires no foreign human or animal products, only the patient’s own serum, and is completely non-invasive. This preliminary trial was conducted on three people, two with extensive corneal damage resulting from multiple surgeries to remove ocular melanomas, and one with the genetic eye condition aniridia. The patient with aniridia had damage in both eyes so stem cells were taken from the conjunctiva area. Because stem cells have not yet differentiated into specific cells they could grow into the cells that were needed. Each patient’s sight improved significantly after only a couple of months

Here is how it works. Less than a millimeter of tissue is taken from the ocular surface of the patients own eye. It takes a couple of hours to prepare the eye and put the contact lens with the baby cells in place and the patient goes home. The stem cells are cultured on a post surgical contact lens which is then placed onto the damaged cornea for 10 days, during which time the cells are able to re-colonise and heal the damaged eye surface. Apparently it took some experimentation to find a lens that could be successfully used as a scaffold for the cells.

The scientists on this research project see this therapy as a simple way to restore sight for eyes damaged by scarring, chemotherapy and a range of other disorders. They suggest that all is needed is a simple lab and qualified medical personnel putting it within reach of even third world countries

Di Girolamo, Nick; Bosch, Martina; Zamora, Katherine; Coroneo, Minas T.; Wakefield, Denis; Watson, Stephanie L. A Contact Lens-Based Technique for Expansion and Transplantation of Autologous Epithelial Progenitors for Ocular Surface Reconstruction. Transplantation, 2009; 87 (10): 1571 DOI: 10.1097/TP.0b013e3181a4bbf2

On the other hand, when dopamine levels are too high, they tend to reduce the amount of endorphins available for pain relief. That may be why antidepressants that are designed to reduce dopamine levels sometimes relieve chronic pain–they allow endorphin levels to stay higher than when excessive dopamine is present. Vigorous exercise and sweets can increase Dopamine, moderate exercise releases endorphins. Because drugs that increase dopamine, like amphetamines, promote wakefulness, the findings offer a potential mechanism explaining how the brain helps people stay awake despite the urge to sleep.

The study also shows that the increase in dopamine cannot compensate for the cognitive deficits caused by sleep deprivation. Given this research it seems that depression, brain fog, chronic pain, weight gain and insomnia may be trauma related rather than social psychological factors as previously imagined